D-dimer is a small protein fragment released when the body breaks down a blood clot. A blood test measures it to help assess whether a harmful clot might be present. A high result alone does not prove that there is a clot.
A clot in a deep vein or in the lungs can raise D-dimer. Pregnancy, recent surgery and other conditions can also raise it. The blood test cannot show where a clot is. Depending on the findings, an ultrasound or another scan may be needed.
A negative test is useful when the clinician has already assessed the likelihood of a clot as low. It should not be used on its own to dismiss concerning symptoms. Blood-thinning treatment can also affect the result.
Sudden difficulty breathing or chest pain needs urgent medical assessment. Do not wait for a test result or use a previous normal D-dimer result to explain away new symptoms.

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