Cryoglobulins are proteins in the blood that can form clumps when cooled. The clumps dissolve again when warmed. Most are antibodies, which are proteins made by the immune system. A blood test looks for this behaviour.
It shows that cryoglobulins were found. Further laboratory work can identify their type. They may occur with some infections, immune-system conditions or blood disorders, so the result alone does not identify the cause.
The clinician considers the result alongside symptoms, such as skin changes, and other findings. The type of cryoglobulin helps guide the investigation.
The blood must be kept warm during the early collection and separation steps. The laboratory then cools the separated sample under controlled conditions. Follow the testing service's collection instructions; ordinary handling may not be suitable for this test.

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