Ceruloplasmin blood test
Explanation
Ceruloplasmin is a protein made by the liver that carries copper in the blood. Its level can help investigate problems with how the body handles copper, usually together with other tests.
Does a low result mean Wilson disease?
Not necessarily. Wilson disease is an inherited condition in which copper can build up in organs. Ceruloplasmin is often low, but some people with Wilson disease have a normal result.
Low levels can also occur with a shortage of copper, severe liver disease or some kidney conditions. A low ceruloplasmin level is not, by itself, a measure of how much copper has collected in the body.
Which other findings help?
The clinician may compare blood and urine copper results, liver tests, symptoms and family history. Further tests depend on what this combination suggests.
High ceruloplasmin can occur during inflammation or infection. Pregnancy and estrogen-containing medicines can also raise it. Ask how the result fits with the other copper tests rather than interpreting the number on its own.
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