C-peptide is released when the pancreas makes insulin, the hormone that helps sugar enter cells for energy. Measuring C-peptide helps estimate how much insulin the body makes itself. Injected insulin does not contain C-peptide.
The test can help assess insulin production in someone with diabetes or investigate unexplained low blood sugar. It may help clarify the type of diabetes when other information is uncertain. It is not the usual test for diagnosing diabetes itself.
A low result can suggest reduced insulin production. A high result can occur when the body makes more insulin, but kidney problems can also affect the level. The value needs to be read with blood sugar and other clinical information.
Some samples are taken after fasting and others after food or a test drink. These conditions affect interpretation. Ask how the sample was collected and whether the blood sugar measured at the same time helps explain the result.

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