BCR-ABL1 test
Explanation
BCR-ABL1 is a gene change found in certain blood cancers. It forms when parts of two genes join together. Testing blood or bone marrow for this change can help diagnose a condition and monitor its treatment.
Is this an inherited change?
The BCR-ABL1 change develops in affected cells during life. It is not the same as an inherited gene change passed from a parent to a child. Chromosomes are structures in cells that carry genes. The changed chromosome associated with BCR-ABL1 is called the Philadelphia chromosome.
What does a positive result tell the team?
The finding is closely linked with chronic myeloid leukemia and also occurs in some other leukemias. The clinician combines it with blood counts and other findings to establish the diagnosis and choose treatment.
Why is the amount measured repeatedly?
During treatment, changes in the amount detected help show the response. A falling level can indicate that treatment is working. A rising result needs assessment, but its meaning depends on the method and earlier measurements. Using comparable tests, usually from the same laboratory, makes trends easier to interpret.
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